Effect of Red Gedi Leaf Extract (Abelmoschus manihot) (L). Medik on Total Cholesterol of Hypercholesterolemia Diabetic Male Rat

Pengaruh Ekstrak Daun Gedi Merah (Abelmoschus manihot) (L). Medik) pada Kadar Kolesterol Total Tikus Putih Jantan Hiperkolesterolemia Diabetes

Abstract

Gedi Red Leaf is a plants that contains chemicals such as alkaloids, flavonoids, saponins, tannins and polyphenols. This study aims to prove the ability of ethanol extract of red gedi leaf (Abelmoschus manihot (L.) Medik) in lowering total cholesterol levels of the male white rat model of diabetes and hypercholesterolemia, dosing leaf extract of red gedi mostly effective in lowering total cholesterol levels in white rats male. Gedi red leaf extract made by maceration with 96%. The design of the study was a randomized block design (RBD). Data were analyzed using statistical tests one way (ANOVA) at the level of 95% used 42 male rats which were divided into six treatment groups, each treatment consisting of 7 animals. Group I as a negative control by suspense Na CMC 0.5%, group II as a control pain by Na-CMC suspension 0.5%, Group III as a positif control by the suspension of simvastatin 0.9 mg / kg BW, groups IV, V and VI were given ethanol extract of leaf of red gedi, each with a dose of 150 mg/ kg BW, 300 mg/ kg BW and 450 mg/ kg BW. All treatment groups were given high-cholesterol feed except fructose synthetic and negative groups. Based on Duncan test it shows that the dose of ethanol extract of leaf of red gedi effective is 450 mg / kg BW.